The Mitochondrial Recycling Truck: Why Aging Cells Can't Clear Broken Power Plants — and Set Themselves on Fire

Mitophagy — the cell's recycling system for damaged mitochondria — slows with age, letting broken units pile up and leak bacterial-like mtDNA that triggers chronic inflammation. Four 2026 studies show restarting this pathway in rheumatoid arthritis and Alzheimer's models suppresses downstream inflammasome activation, while a fourth study reveals selective autophagy extends well beyond mitochondria.

react-doctor: Zero-Config React Code Quality Scanner with Agent Skill Support

A deterministic CLI that scans your React codebase for state management, performance, security, and accessibility issues. Best for teams using AI coding agents alongside React. Free, zero-install via npx, with built-in GitHub Actions integration. Telemetry is on by default but can be disabled.

Cohort Explorer

• Cohort Explorer launched: upload any tabular dataset for descriptive statistics, automatic bivariate test selection, an auto-generated Table 1, and a correlation heatmap
• Supports direct paste from Excel or Google Sheets, plus CSV/TSV file upload

learn-harness-engineering: A Systematic Course on AI Coding Agent Harness Design

A 12-lecture open-source course that teaches you how to build reliable AI coding agent sessions through structured harness engineering. Best for developers who already use AI agents but struggle with consistency. The bundled harness-creator skill alone is worth a look. Limited by its Electron-app focus.

dose-response

• Four-parameter logistic (4PL) dose-response fitting for IC50 and EC50, with bottom, top, Hill slope, R-squared, and RMSE
• Server compute engine keeps the fitting implementation off the public bundle while staying free and open without sign-in
• Response modes for viability, signal, and inhibition assays, with an optional 0-100 normalization toggle
• Fitted curve chart on a log10 dose axis, prediction and residual table, fit-quality warnings, and CSV export
• Shared 4PL core reused by the upcoming ELISA standard-curve interpolation tool